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- Inspired by personal experiences, 50/50 is an original story about friendship, love, survival and finding humor in unlikely places. Joseph Gordon-Levitt and Seth Rogen star as best friends whose lives are changed by a cancer diagnosis in this new comedy directed by Jonathan Levine from a script by Will Reiser. 50/50 is the story of a guy's transformative and, yes, sometimes funny journey to health - drawing its emotional core from Will Reiser's own experience with cancer and reminding us that friendship and love, no matter what bizarre turns they take, are the greatest healers.
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